Our computer model projects a victory for the San Francisco 49ers when they meet the Arizona Cardinals at Levi's Stadium on Sunday, October 1 at 4:25 PM ET -- for a full breakdown regarding the spread, over/under and final score, continue reading.

The 49ers have been surging on both offense and defense, ranking third-best in scoring offense (30 points per game) and fifth-best in scoring defense (14 points allowed per game). With 24 points per game on the offensive side of the ball, the Cardinals rank 13th in the NFL. On defense, they rank 15th, surrendering 22.3 points per game.

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49ers vs. Cardinals Predictions and Picks

ATS Over/Under Score Prediction
Cardinals (+14.5) Over (44) 49ers 29, Cardinals 16

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49ers Betting Info

  • Based on this game's moneyline, the 49ers have an implied win probability of 91.7%.
  • San Francisco has a record of 2-0-1 against the spread this season.
  • So far this season, one San Francisco game has hit the over.
  • 49ers games this season have posted an average total of 43.5, which is 0.5 points fewer than the total for this matchup.

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Cardinals Betting Info

  • The bookmakers' moneyline implies a 12.5% chance of a victory for the Cardinals.
  • Arizona is 3-0-0 ATS this season.
  • This year, games featuring Arizona have hit the over twice.
  • The over/under for this game is 3.8 points higher than the average scoring total for Cardinals games (40.2).

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49ers vs. Cardinals 2023 Scoring Insights

Pts Pts Allowed Home Pts Home Pts Allowed Away Pts Away Pts Allowed
San Francisco 30 14 30 12 30 15
Arizona 24 22.3 28 23.5 16 20

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