Giants vs. Padres Predictions & Picks: Odds, Moneyline, Spread - September 26

Tuesday's contest features the San Diego Padres (77-80) and the San Francisco Giants (78-79) facing off at Oracle Park in what should be a tight matchup, with a projected 6-4 victory for the Padres according to our computer prediction. First pitch is at 9:45 PM ET on September 26.

The Padres will give the nod to Seth Lugo (7-7) versus the Giants and Kyle Harrison (1-1).

Giants vs. Padres Game Info & Odds

• When: Tuesday, September 26, 2023 at 9:45 PM ET
• Where: Oracle Park in San Francisco, California
• How to Watch on TV: MLB Network
• Live Stream: Watch this game on Fubo!

Bet on this matchup with BetMGM Sportsbook and use bonus code "GNPLAY" for special offers!

Giants vs. Padres Score Prediction

Our prediction for this contest is Padres 6, Giants 5.

Total Prediction for Giants vs. Padres

• Total Prediction: Over 8 runs

Sportsbook Promo Codes

Explore More About This Game

• Giants Injury Report

• Padres vs Giants Betting Trends & Stats

• Padres vs Giants Pitching Matchup

• How to Watch Padres vs Giants

• Padres vs Giants Odds

• Padres vs Giants Player Props

Giants Performance Insights

• In six games as the underdog over the last 10 matchups, the Giants have posted a mark of 2-4.
• In its previous 10 matchups with a total posted by oddsmakers, San Francisco and its opponents are 4-5-1 when it comes to hitting the over.
• The last 10 Giants games have not had a spread posted by oddsmakers.
• The Giants have won in 30, or 43.5%, of the 69 contests they have been named as odds-on underdogs this year.
• This season, San Francisco has come away with a win 17 times in 48 chances when named as an underdog of at least +105 or worse on the moneyline.
• The Giants have an implied victory probability of 48.8% according to the moneyline set for this matchup.
• San Francisco scores the 23rd-most runs in baseball (666 total, 4.2 per game).
• The Giants have the 12th-ranked ERA (4.08) in the majors this season.

Put your picks to the test and bet on with BetMGM Sportsbook. Use bonus code "GNPLAY" for special offers!

Giants Schedule