Giants vs. Dodgers Predictions & Picks: Odds, Moneyline, Spread - September 22

Friday's contest that pits the Los Angeles Dodgers (94-58) versus the San Francisco Giants (76-77) at Dodger Stadium has a projected final score of 6-3 (based on our computer prediction) in favor of the Dodgers, who is favored in this matchup by our model. First pitch is at 10:10 PM ET on September 22.

The Dodgers will give the nod to Caleb Ferguson (7-3, 2.88 ERA), who is eyeing win No. 8 on the season, and the Giants will turn to Sean Manaea (6-6, 4.73 ERA).

Giants vs. Dodgers Game Info & Odds

• When: Friday, September 22, 2023 at 10:10 PM ET
• Where: Dodger Stadium in Los Angeles, California
• How to Watch on TV: Apple TV+
• Live Stream: Watch this game on Fubo!

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Giants vs. Dodgers Score Prediction

Our pick for this matchup is Dodgers 6, Giants 3.

Total Prediction for Giants vs. Dodgers

• Total Prediction: Over 9 runs

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Explore More About This Game

• Giants Injury Report

• Dodgers vs Giants Betting Trends & Stats

• Dodgers vs Giants Pitching Matchup

• How to Watch Dodgers vs Giants

• Dodgers vs Giants Odds

Giants Performance Insights

• Over their last 10 contests, the Giants were named underdogs twice and lost each contest.
• In its previous 10 games with a total, San Francisco and its opponents have combined to exceed the over/under on six occasions.
• The Giants have had a spread set in one of their past 10 games, and they have fallen short of covering the spread each time.
• The Giants have come away with 28 wins in the 65 contests they have been listed as the underdogs in this season.
• This year, San Francisco has won three of eight games when listed as at least +145 or worse on the moneyline.
• The moneyline set for this matchup implies the Giants have a 40.8% chance of walking away with the win.
• Averaging 4.3 runs per game (657 total), San Francisco is the 22nd-highest scoring team in MLB.
• The Giants have the 12th-ranked ERA (4.12) in the majors this season.

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