The San Francisco 49ers are +600 to win the Super Bowl, which are the best odds in the entire NFL as of September 22.

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49ers Super Bowl Odds

  • Odds to Win the NFC West: -649
  • Odds to Win the Super Bowl: +600

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San Francisco Betting Insights

  • San Francisco won 11 games against the spread last season, failing to cover six times.
  • Last season, nine 49ers games went over the point total.
  • San Francisco surged on both offense and defense last season, ranking fifth-best in total offense (365.6 yards per game) and best in total defense (300.6 yards allowed per game).
  • At home last year, the 49ers were 8-1. On the road, they were 5-3.
  • San Francisco won one game as an underdog (1-1) a year ago, and went 12-3 as the favored team.

49ers Impact Players

  • On the ground, Christian McCaffrey had eight touchdowns and 1,139 yards (67.0 per game) last year.
  • McCaffrey also had 85 catches for 741 yards and five TDs.
  • Brandon Aiyuk had 78 receptions for 1,015 yards (59.7 per game) and eight touchdowns in 17 games.
  • George Kittle had 60 catches for 765 yards (51.0 per game) and 11 touchdowns in 15 games a season ago.
  • In the passing game, Deebo Samuel scored two TDs, hauling in 56 balls for 632 yards (48.6 per game).
  • As a tone-setter on defense, Nick Bosa totaled 51 tackles, 19.0 TFL, and 18.5 sacks in 16 games last year.

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49ers Player Futures

Christian McCaffrey Offensive Player of the Year Odds
George Kittle MVP Odds
Fred Warner Defensive Player of the Year Odds
Deebo Samuel MVP Odds
Nick Bosa Defensive Player of the Year Odds
Brandon Aiyuk Offensive Player of the Year Odds
Brock Purdy MVP Odds
Elijah Mitchell Offensive Player of the Year Odds
Talanoa Hufanga Defensive Player of the Year Odds

2023-24 49ers NFL Schedule

Week Date Opponent Result Opp. Super Bowl Odds
1 September 10 @ Steelers W 30-7 +4000
2 September 17 @ Rams W 30-23 +8000
3 September 21 Giants W 30-12 +10000
4 October 1 Cardinals - +100000
5 October 8 Cowboys - +800
6 October 15 @ Browns - +4000
7 October 23 @ Vikings - +8000
8 October 29 Bengals - +2000
BYE - - - -
10 November 12 @ Jaguars - +2500
11 November 19 Buccaneers - +6600
12 November 23 @ Seahawks - +4000
13 December 3 @ Eagles - +750
14 December 10 Seahawks - +4000
15 December 17 @ Cardinals - +100000
16 December 25 Ravens - +1200
17 December 31 @ Commanders - +8000
18 January 7 Rams - +8000

Odds are current as of September 22 at 7:13 PM ET. Not all offers available in all states, please visit BetMGM for the latest promotions for your area. Must be 21+ to gamble, please wager responsibly. If you or someone you know has a gambling problem, contact 1-800-GAMBLER.