According to sportsbooks, the San Francisco 49ers (2-0) are double-digit, 10.5-point favorites heading into their matchup on Thursday, September 21, 2023 against the New York Giants (1-1). The game's total has been listed at 43.5 points.

Before the 49ers square off against the Giants, prepare for the matchup by taking a look at their betting insights and trends. Here's a look at the betting trends and insights for the Giants as they ready for this matchup against the 49ers.

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49ers vs. Giants Odds, Spread, Over/Under

Take a look at the odds, spread and over/under for this matchup available at multiple sportsbooks.

Favorite Total San Francisco Moneyline New York Moneyline
BetMGM 49ers (-10.5) 43.5 -600 +425 Bet on this game with BetMGM
FanDuel 49ers (-10.5) 43.5 -650 +480 Bet on this game with FanDuel

Other Week 3 Odds

San Francisco vs. New York Game Info

  • When: Thursday, September 21, 2023 at 8:15 PM ET
  • Where: Levi's Stadium in Santa Clara, California
  • TV Info: Amazon Prime Video
  • Live Stream: Watch this game on Fubo!

49ers vs. Giants Betting Insights

  • San Francisco's record against the spread last year was 11-6-0.
  • The 49ers covered every time (1-0) as a 10.5-point favorite or more last year.
  • In 17 San Francisco games last season, nine went over the total.
  • Against the spread, New York was 13-4-0 last year.
  • The Giants covered the spread when playing as at least 10.5-point underdogs in their only opportunity last year.
  • There were seven New York games (out of 17) that hit the over last year.

49ers Player Props

Name Pass Yds Pass TDs Rush Yds Rush TDs Rec Yds Rec TDs
George Kittle - - - - 42.5 (-118) -
Christian McCaffrey - - 78.5 (-128) - 29.5 (-120) -
Brock Purdy 228.5 (-115) - 7.5 (-115) - - -
Deebo Samuel - - 14.5 (-115) - 53.5 (-115) -

Payouts above are for the "over" bet.

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