The San Francisco 49ers' (2-0) injury report heading into their matchup with the New York Giants (1-1) currently has two players. The matchup begins at 8:15 PM on Thursday, September 21 from Levi's Stadium.

The 49ers enter the matchup after winning 30-23 over the Los Angeles Rams in their last outing on September 17.

Last time out, the Giants won 31-28 over the Arizona Cardinals.

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San Francisco 49ers Injury Report Today

Player Pos. Injury Status
Brandon Aiyuk WR Shoulder Questionable
Ambry Thomas CB Knee Questionable

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New York Giants Injury Report Today

Player Pos. Injury Status
Saquon Barkley RB Ankle Out
Ben Bredeson OG Concussion Out
Andrew Thomas OT Hamstring Out
Azeez Ojulari OLB Hamstring Out
Micah McFadden LB Neck Questionable
Wan'Dale Robinson WR Knee Questionable

49ers vs. Giants Game Info

  • When: Thursday, September 21, 2023 at 8:15 PM ET
  • Where: Levi's Stadium in Santa Clara, California
  • TV Info: Amazon Prime Video
  • Live Stream: Watch this game on Fubo

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49ers Season Insights (2022)

  • The 49ers clicked on all fronts last season, as they ranked fifth-best in total offense (365.6 yards per game) and best in total defense (300.6 yards allowed per game).
  • San Francisco ranked sixth in points scored last season (26.5 points per game), but it excelled on the other side of the ball, ranking best in the NFL with 16.3 points allowed per game.
  • The 49ers ranked 13th in pass offense (226.8 passing yards per game) and 20th in pass defense (222.9 passing yards allowed per game) last season.
  • San Francisco ranked eighth in rushing yards last year (138.8 rushing yards per game), but it thrived on the defensive side of the ball, ranking second-best in the NFL with 77.7 rushing yards allowed per game.
  • The 49ers forced 30 total turnovers (second in NFL) last season and turned it over 17 times (third in NFL) for a turnover margin of +13, the best in the NFL.

49ers vs. Giants Betting Info

  • Spread Favorite: 49ers (-10.5)
  • Moneyline: 49ers (-600), Giants (+425)
  • Total: 43.5 points

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