The New York Giants (1-1) hit the road to square off against the San Francisco 49ers (2-0) at Levi's Stadium on Thursday, September 21, 2023, and here are our best bets.

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When is 49ers vs. Giants?

  • Game Date: Thursday, September 21, 2023
  • Time: 8:15 PM ET
  • TV: Amazon Prime Video
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Watch the NFL live all season long with Fubo!

Best Moneyline Bet

  • Prediction: San Francisco 39 - New York 8
  • Looking at this matchup's moneyline, the 49ers' implied win probability is 84.3%.
  • The 49ers were favored on the moneyline 16 total times last season. They finished 13-3 in those games.
  • San Francisco played as a moneyline favorite of -535 or shorter in only one game last season, which it won.
  • The Giants won six, or 50%, of the 12 games they played as underdogs last season.
  • Last season, New York was at least a +400 underdog on the moneyline one time, losing that contest.

Who will win? The 49ers or Giants? Head to BetMGM and make your pick!

Against the Spread Pick

  • Pick ATS: San Francisco (-10.5)
  • The 49ers beat the spread 11 times in 17 games last year.
  • San Francisco covered every time (1-0) as a 10.5-point or higher favorite last year.
  • Against the spread, the Giants were 13-4-0 last season.
  • New York covered every time (1-0) as underdogs of 10.5 points or greater last year.

Parlay your bets together on the 49ers vs. Giants matchup with BetMGM, where you can use our link to get a great first-time player bonus!

Best Over/Under Pick

  • Pick OU: Over (43.5)
  • The two teams averaged a combined 4.5 more points per game (48) a season ago than this matchup's over/under of 43.5 points.
  • Opponents of these teams averaged a combined 38.1 points per game last season, 5.4 less than the over/under for this game.
  • Last season, nine of the 49ers' games went over the point total.
  • In Giants games last season, combined scoring went over the point total seven times.

Expecting a high-scoring contest or a defensive masterclass? Check out the alternate markets and ways you can bet on this matchup with BetMGM, using our link for a bonus offer for new players.

Christian McCaffrey Rushing Attempts (Our pick: 17.5/Under)

Games Rush YPG Rush TDs Rec. YPG Rec. TDs
2 134 2 18 0

Daniel Jones Passing Touchdowns (Our pick: 1.5/Under)

Games Pass YPG Pass TDs Rush YPG Rush TDs
2 212.5 2 51 1

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