According to sportsbooks, the Los Angeles Rams (1-0) are touchdown underdogs in a home NFC West matchup with the San Francisco 49ers (1-0) on Sunday, September 17, 2023 at SoFi Stadium. A point total of 45 has been set for this matchup.

Before the 49ers take on the Rams, here are their betting trends and insights. The recent betting trends and insights for the Rams can be found in this article before they face the 49ers.

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49ers vs. Rams Odds, Spread, Over/Under

See the odds, spread and over/under for this matchup at different sportsbooks.

Favorite Total San Francisco Moneyline Los Angeles Moneyline
BetMGM 49ers (-7) 45 -350 +260 Bet on this game with BetMGM
FanDuel 49ers (-7) 45.5 -330 +265 Bet on this game with FanDuel

Other Week 2 Odds

San Francisco vs. Los Angeles Game Info

  • When: Sunday, September 17, 2023 at 4:05 PM ET
  • Where: SoFi Stadium in Inglewood, California
  • TV Info: FOX
  • Live Stream: Watch this game on Fubo!

49ers vs. Rams Betting Insights

  • San Francisco had 11 wins in 17 games against the spread last year.
  • The 49ers went 5-2 ATS as 7-point favorites or more last season.
  • There were nine San Francisco games (out of 17) that hit the over last season.
  • Los Angeles covered the spread six times in 17 games last season.
  • The Rams were an underdog by 7 points or more last year twice, and failed to cover both times.
  • In 17 Los Angeles games last year, six of them hit the over.

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