Our computer model projects a victory for the San Francisco 49ers when they play the Los Angeles Rams at SoFi Stadium on Sunday, September 17 at 4:05 PM ET -- for a full breakdown regarding the spread, over/under and final score, continue reading.

The 49ers found success on both offense and defense last season, ranking fifth-best in total offense (365.6 yards per game) and best in total defense (300.6 yards allowed per game). The Rams were a bottom-five offense last season, ranking worst with 280.5 yards per game. On defense, they ranked 19th in the NFL (341.1 yards allowed per game).

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49ers vs. Rams Predictions and Picks

ATS Over/Under Score Prediction
Toss Up (Spread: 49ers by 7) Under (45.5) 49ers 24, Rams 16

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49ers Betting Info

  • The implied moneyline probability in this matchup gives the 49ers a 77.8% chance to win.
  • San Francisco won 11 games against the spread last season, failing to cover six times.
  • The 49ers were favored by 7 points or more seven times last season, and covered the spread in five of those matchups.
  • Last season, the combined scoring went over the point total nine times in San Francisco games.
  • The over/under in this game is 45.5 points, 3.3 higher than the average total in 49ers games last season.

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Rams Betting Info

  • Oddsmakers have implied with the moneyline set for this matchup that the Rams have a 27.8% chance to win.
  • Los Angeles covered six times in 17 chances against the spread last season.
  • The Rams were an underdog by 7 points or more last season twice, and failed to cover both times.
  • Los Angeles games hit the over six out of 17 times last year.
  • The over/under for this game is 3.2 points higher than the average scoring total for Rams games last season (42.3).

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49ers vs. Rams 2022 Scoring Insights

Pts Pts Allowed Home Pts Home Pts Allowed Away Pts Away Pts Allowed
San Francisco 26.5 16.3 28 14.8 24.8 18
Los Angeles 18.1 22.6 21.9 22.8 13.8 22.4

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