Brett Anderson struck out 10 more Houston batters and the Oakland Athletics backed him with three home runs for a 9-3 win Sunday and a three-game sweep of the Astros.
Coco Crisp, Jed Lowrie and Chris Young homered for Oakland, sending Houston to its fifth straight loss.
The Astros, playing their first year in the American League, went 1-5 on their season-opening homestand against Texas and Oakland. They'll now start a nine-game road trip to the West Coast against division opponents.
Anderson (1-1) and the A's bullpen combined for 14 strikeouts. The Astros have fanned 74 times overall in six games.