EUGENE, Ore. (AP) - Jeremiah Masoli threw for 222 yards and a touchdown and ran for 164 more yards with another score and the No. 10 Oregon Ducks ran past No. 4 USC 47-20 for the Trojans' worst loss since 1997.
Redshirt freshman LaMichael James ran for 184 yards and a score as the Ducks (7-1, 5-0 Pacific-10) racked up 391 yards on the ground against the Trojans, who came into the game with the fifth-best rush defense in the nation, allowing an average of just 79.9 yards a game.
Southern California (6-2, 3-2) had not lost a game by more than a touchdown since a 27-16 loss to Notre Dame in 2001, Pete Carroll's first season as coach. It was USC's worst lost since a 35-7 defeat to Arizona State on Oct. 11, 1997.
Oregon remained undefeated in the Pac-10, threatening USC's hold on the league championship for the past seven years.