SAN FRANCISCO (AP) - Frank Gore's spectacular day single-handedly re-established the run game for San Francisco.
Gore had touchdown runs of 79 and a career-best 80 yards and finished with 207 yards on 16 carries, and the 49ers beat the Seattle Seahawks 23-10 to take an early hold atop the NFC West standings.
Gore, who surpassed San Francisco's Week 1 rushing total of 21 yards in the first series, nearly reached his franchise mark of 212 yards set in 2006 before leaving the game in the fourth quarter with a sprained right ankle that didn't appear serious. He became only the second player in NFL history to have two TD runs of 79 or more yards in the same game, joining Barry Sanders. Sanders had runs of 80 and 82 yards at Tampa Bay on Oct. 12, 1997.
Seattle (1-1), coming off a 28-0 season-opening win at St. Louis, took a big blow losing quarterback Matt Hasselbeck to a rib injury just before halftime following a hard hit near the goal line by Patrick Willis. Hasselbeck didn't return after completing 10 of 18 passes for 97 yards and no touchdowns.