Brandon Meredith hit two home runs and Tyler Lavigne pitched into the eighth inning as San Diego State eliminated defending College World Series champion Fresno State in the Irvine, Calif., regional.
Coach Tony Gwynn's Aztecs (41-22) will face the loser of the UC Irvine-Virginia matchup in an elimination game Sunday.
Fresno State's defense of its national title ended in two regional losses as Lavigne limited the Bulldogs (32-30) to just five hits and an unearned run in 7 1/3 innings while striking out eight and walking one. Addison Reed got four outs for his 20th save.
Kenny Wise accounted for Fresno's only run with a fourth-inning triple that scored Brennan Gowens.