Key developments on swine flu outbreaks, according to the U.S. Centers for Disease Control and Prevention, the World Health Organization and government officials:
-Deaths: 48 in Mexico; two in the U.S., both in Texas; one in Canada and one in Costa Rica. One of those who died in the U.S. was a toddler from Mexico. Officials said the Canadian, U.S. and Costa Rican victims also had other underlying medical conditions.
-Confirmed cases: more than 4,100 in 29 countries, including at least 1,578 in Mexico, at least 2,254 in the United States and 247 in Canada.
-Japan reported its first three cases Saturday, an airport quarantine official told The Associated Press. Public broadcaster NHK said the two teenage boys and a teacher were returning from Canada. Australia reported its first confirmed case Saturday.
-President Barack Obama sought to reassure Hispanics that swine flu won't lead to epidemic of discrimination in the United States just because Mexico has been the center of the outbreak.
-Mexico's U.N. envoy says nations need common rules for responding to flu outbreaks to prevent discrimination and unfair trade restrictions; says Mexicans unfairly singled out.
-WHO says up to 2 billion people could be infected by swine flu if outbreak turns into pandemic over months or years. But WHO flu chief Keiji Fukuda says it's too early to tell how widespread or severe the outbreak will become.
-High schools, universities, dance halls, movie theaters and bars have reopened across Mexico. Primary schools will reopen next week.
-About one in 10 Americans have stopped hugging and kissing close friends or relatives because of concerns about swine flu, according to a Harvard study.
-CDC says only about 10 percent of Americans with swine flu are
believed to have gotten it during trips to Mexico.