Sources: 49ers' Alex Smith Out; Kaep In

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SAN FRANCISCO, Calif. - Colin Kaepernick to make first career start for the San Francisco 49ers on Monday Night Football.

The 49ers starting quarterback Alex Smith has been ruled out for the game against the Chicago Bears after he was unable to get clearance from a neurologist one week after suffering a concussion, according to ESPN.

The Former Nevada Wolf Pack Quarterback takes Smith's place in a game that will also feature Jason Campbell as the Bears' starter because Jay Cutler has been declared out, also because of a concussion.

Smith, who is ranked third in the NFL with a 104.1 passer rating, practiced in a non-contact black jersey last week and took part in most of the drills involving the first-team offense.

Smith, who has made 28 consecutive starts, was injured during the first half of a 24-24 tie with the St. Louis Rams in Week 10 and left the game midway through the second quarter.

Kaepernick replaced Smith after the injury and was 11 of 17 for 117 yards and rushed for 66 yards and a touchdown against St. Louis.